Nangia A Supramolecular Synthons in Crystal Engineering of Pharma Prop 2025
General:
Name: Nangia A Supramolecular Synthons in Crystal Engineering of Pharma Prop 2025
Format: pdf
Size: 14.91 MB
Book:
Title: Supramolecular Synthons in Crystal Engineering of Pharmaceutical Properties
Author: Ashwini K. Nangia
Language: polski
Year: 2024
Subjects: Science & Technology, Medicine & Nursing, Chemistry, Medicine, Chemistry – Biochemistry, Basic Sciences, Biochemistry – General & Miscellaneous, Pathology
Publisher: CRC Press
ISBN: 9781040124697
Total pages: 197
Description:
This comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers.
Key Features
- Covers the fundamentals of crystal engineering and supramolecular synthons.
- Details the challenges of low solubility and low permeability facing oral drug formulations.
- Explains how heterosynthons provide a rational approach to address and implement solutions.
- Provides case studies from academic and industrial labs to walk the reader through the actual steps.
- Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry.
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